Rationale for the use of Doramycin for the eradication of microflora associated with bacterial vaginosis
Authors: P.V. Fedorych, G.I. Mavrov, Vl.V. Podolsky
The objective: to substantiate the use of the antimicrobial drug Doramycin (spiramycin) in the treatment of bacterial vaginosis (BV), taking into account the sensitivity to it of the individual components of the polyetiological disease.
Materials and methods
Using the real-time polymerase chain reaction method, a DT-96 amplificator using the Femoflor-16 reagent kit was used to examine 71 patients with chronic inflammation of the genitourinary system, in whom microorganisms associated with BV were detected. The sensitivity of the detected microflora to Doromycin has been analyzed.
Results
The overwhelming majority of microorganisms and / or groups of microorganisms (sensitivity to part of the constituent groups) associated with BV, which can be detected using the Femoflor-16 reagent kit, has been shown to be sensitive to Doramycin.
Conclusion
Doramycin is advisable to use as a drug of choice for the comprehensive treatment of bacterial vaginosis in women, as well as anaerobic and microaerophilic dysbiosis of the urinary system of men. The main additional benefits of Doromycin are the possibility of prescribing the drug during pregnancy, as well as the possibility of simultaneous eradication of both certain causative agents of bacterial vaginosis, and Chlamydia trachomatis and Ureaplasma urealyticum, the most common causative agents of inflammation of the genitourinary system today.
Key words: Doramycin, spiramycin, bacterial vaginosis, treatment, Femoflor-16 reagent kit.
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